T deficiency is a prevalent medical condition. T deficiency can arise for a number of reasons:
(e.g. in chemotherapy, AIDS, chronic lung disease and renal failure, cirrhosis, opioid treatment and critical illness).
Source: Lancet Diabetes Endocrinol . 2024 Oct;12(10):761-774; Cureus 2025 Feb 9;17(2):e78785
Current treatments may carry high risk for patients treated with TRT:
High blood pressure
Although controversial, it may promote prostate tumorigenesis
May reduce intratesticular T
and sperm numbers
leading to infertility
*”A black box warning is the FDA’s most stringent warning for drugs and medical devices on the market alerting the public and health care providers to serious side effects, such as injury or death” https://www.drugwatch.com/fda/black-box-warnings